Immediately stop treatment in case of serious allergic/hypersensitivity reactions including SJS. Avoid in patients w/ pre-existing major CV diseases (eg, MI, stroke or unstable angina). Do not start treatment until an acute attack of gout has completely subsided. Risk of gout flares at treatment initiation. Not recommended in patients whom the rate of urate formation is greatly increased (eg, malignant disease & its treatment, Lesch-Nyhan syndrome); organ transplant patients. Perform LFT prior to treatment initiation w/ febuxostat & periodically thereafter based on clinical judgment. Caution in patients w/ altered thyroid function. Not recommended w/ concomitant mercaptopurine/azathioprine. Patients w/ rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Exercise caution before driving, using machinery or participating in dangerous activities. Should not be used during pregnancy & breastfeeding.
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